Human Pathophysiology Book – The Origin of Why

Authors

Galo Juvenal Vinueza Aguay, Hospital General Docente Ambato, (Ecuador).; Michelle Lissette Zambrano Zambrano, Consultorio Médico MediK VitaLZ, (Ecuador).; Klever Roberto Leguizamo Silva, Consultorio Médico MediK VitaLZ, (Ecuador).; Sandra Lucía Córdova Solórzano, Hospital General Docente Ambato, (Ecuador).; Sergio Javier Vinueza López, Pontificia Universidad Católica del Ecuador, (Ecuador).; Mario Leopoldo Sunta Ruiz, Hospital General Docente Ambato, (Ecuador).; Verónica Elizabeth Padilla Vinueza, Ministerio de Salud Pública, (Ecuador).; Katherine Elizabeth Garces Jerez, Ministerio de Salud Pública, (Ecuador).; Galo Daniel Vinueza López, Hospital General Docente Ambato, (Ecuador).; Milton Fabian Tenelema Chango, Investigador independiente, (Ecuador).; Mario David Chávez Lucio, Universidad Técnica de Ambato, (Ecuador).; Johana Estefanía Guevara Lascano, Investigador independiente, (Ecuador).; Carlos Daniel Lucio López, Universidad Técnica de Ambato, (Ecuador).; Santiago Esteban Benítez Sanmartín, Investigador independiente, (Ecuador).; Melanie Samantha Armas Ingavélez, Ministerio de Salud Pública, (Ecuador).; Stephany Raquel Núñez Aldaz, Investigador independiente, (Ecuador).; Diana Carolina Pinto Vera, Universidad Técnica de Ambato, (Ecuador).; Clara Lissete Guamán Naranjo, Hospital General Docente Ambato, (Ecuador).

Keywords:

Human Pathophysiology, Homeostasis, Pathological Processes

Synopsis

The book Human Pathophysiology: The Origin of Why is an academic work focused on the comprehensive study of the pathophysiological mechanisms that explain the origin, development, and clinical manifestation of major human diseases. The book systematically addresses the anatomical, physiological, and biochemical foundations that underlie the disruption of homeostasis in different organs and systems, enabling an understanding of the relationship between the cause of a disease, the resulting functional changes, and its clinical manifestations. Throughout its chapters, various syndromes and pathologies of medical relevance are analyzed, including pain, headache, edema, fever, respiratory failure, obstructive lung diseases, heart failure, arrhythmias, hypertension, acute coronary syndromes, electrolyte imbalances, acid-base disturbances, kidney diseases, and male and female urogenital disorders. Each topic is developed using a didactic structure that integrates definitions, anatomical and physiological principles, pathophysiology, signs and symptoms, clinical cases, assessment questions, and bibliographic references. The work's main contribution lies in explaining the "why" of pathological processes, fostering clinical reasoning and the integration of basic knowledge with clinical practice. It also promotes a critical understanding of the mechanisms involved in the genesis of diseases, facilitating diagnostic interpretation and evidence-based therapeutic decision-making. Due to its broad scope and pedagogical approach, it constitutes a valuable reference resource for students, teachers, and professionals in the health sciences.

Author Biographies

Galo Juvenal Vinueza Aguay, Hospital General Docente Ambato, (Ecuador).

Doctor of Medicine and Surgery, graduated from the Central University of Ecuador, (Ecuador), with 20 years of work experience. Specialist in Emergency and Disaster Medicine, graduated from the Central University of Ecuador, (Ecuador). Postgraduate Diploma in Teaching in Health Sciences, awarded by the Autonomous Regional University of the Andes, (Ecuador).

Michelle Lissette Zambrano Zambrano, Consultorio Médico MediK VitaLZ, (Ecuador).

General Practitioner, graduated from the Technical University of Ambato, (Ecuador), with 4 years of work experience. Master's degree in Hospital Management and Hospital Administration, graduated from the University of the Hemispheres, (Ecuador).

Klever Roberto Leguizamo Silva, Consultorio Médico MediK VitaLZ, (Ecuador).

General Practitioner, graduated from the Technical University of Ambato, (Ecuador), with 2 years of work experience. Master in Public Health with a specialization in Primary Health Care, graduated from the State University of Milagro, (Ecuador).

Sandra Lucía Córdova Solórzano, Hospital General Docente Ambato, (Ecuador).

Licensed in Nursing, graduated from the National University of Loja, (Ecuador), with 23 years of work experience. Postgraduate Diploma in Local Development and Health, awarded by the Private Technical University of Loja, (Ecuador).

Sergio Javier Vinueza López, Pontificia Universidad Católica del Ecuador, (Ecuador).

General Practitioner from the Central University of Ecuador, (Ecuador). Postgraduate student in Neurology at the Pontifical Catholic University of Ecuador, (Ecuador).

Mario Leopoldo Sunta Ruiz, Hospital General Docente Ambato, (Ecuador).

Doctor of Medicine and Surgery, graduated from the Central University of Ecuador, (Ecuador), with 20 years of work experience. Specialist in Emergency and Disaster Medicine, graduated from the Central University of Ecuador, (Ecuador). Specialist in Occupational Toxicology, graduated from the International Private University of SEK, (Ecuador).

Verónica Elizabeth Padilla Vinueza, Ministerio de Salud Pública, (Ecuador).

Physician, graduated from the Technical University of Ambato, (Ecuador) with 13 years of work experience. Specialist in Family and Community Medicine, graduated from the Technical University of Ambato, (Ecuador). Master's candidate in Community Epidemiology, Catholic University of Ecuador, (Ecuador).

Katherine Elizabeth Garces Jerez, Ministerio de Salud Pública, (Ecuador).

Physician, graduated from the Central University of Ecuador,(Ecuador) with 17 years of work experience. Postgraduate Diploma in Health Promotion and Prevention, awarded by the Regional Autonomous University of the Andes. Specialist in Health Project Management, graduated from the Regional Autonomous University of the Andes. Specialist in Family and Community Medicine, graduated from the Technical University of Ambato, (Ecuador). Master's candidate in Teaching in Health Sciences, Ibero-American University of Ecuador, (Ecuador).

Galo Daniel Vinueza López, Hospital General Docente Ambato, (Ecuador).

General Practitioner, graduated from the Technical University of Ambato, (Ecuador), with 10 years of work experience. Specialist in Pediatrics, graduated from the Pontifical Catholic University of Ecuador, (Ecuador).

Milton Fabian Tenelema Chango, Investigador independiente, (Ecuador).

General Practitioner, graduated from the Technical University of Ambato, (Ecuador).

Mario David Chávez Lucio, Universidad Técnica de Ambato, (Ecuador).

Medical student at the Technical University of Ambato, (Ecuador).

Johana Estefanía Guevara Lascano, Investigador independiente, (Ecuador).

Medical Doctor, graduated from the Technical University of Ambato, (Ecuador), with 9 years of work experience. Master's degree in Health Institution Management, graduated from the University of the Americas, (Ecuador).

Carlos Daniel Lucio López, Universidad Técnica de Ambato, (Ecuador).

Medical student at the Technical University of Ambato, (Ecuador).

Santiago Esteban Benítez Sanmartín, Investigador independiente, (Ecuador).

Physician, graduated from the Technical University of Ambato, (Ecuador), with 5 years of work experience. Specialist in Occupational Health and Safety, with a focus on Occupational Health, graduated from the University of the Hemispheres, (Ecuador).

Melanie Samantha Armas Ingavélez, Ministerio de Salud Pública, (Ecuador).

Medical doctor, graduated from the Technical University of Ambato, (Ecuador), with 1 year of work experience.

Stephany Raquel Núñez Aldaz, Investigador independiente, (Ecuador).

General Practitioner, graduated from the Technical University of Ambato, (Ecuador), with one year of work experience.

Diana Carolina Pinto Vera, Universidad Técnica de Ambato, (Ecuador).

Medical student at the Technical University of Ambato, (Ecuador).

Clara Lissete Guamán Naranjo, Hospital General Docente Ambato, (Ecuador).

Medical Doctor, graduated from the Central University of Ecuador, (Ecuador), with 8 years of work experience. Master's degree in Occupational Health and Safety with a specialization in Occupational Risk Prevention, graduated from the SEK International Private University, (Ecuador).

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Published

June 10, 2026

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Physical Dimensions